Organic Synthesis: The Disconnection Approach, 1st edition

Stuart Warren, Paul Wyatt "Organic Synthesis: The Disconnection Approach, 1st edition"
Publisher: Wiley | ISBN: 0470712368 | edition: 1982 | PDF | 344 Pages | 7,9 Mb

Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, “Organic Synthesis: Strategy and Control” and the later chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Summary: organic retrosynthesis support
Rating: 5
This book it is very helpful if you intend to become a complete organic chemist as it provides useful and helful approches to retrosynthetic disconnections. I would suggest any beginner chemist like me to consult it and eventually buy it.
Summary: Organic Synthesis Textbook ...
Rating: 5
I find the information within this textbook very helpful. I am going to use it as a guidline for teaching my Advanced Organic Chemistry course for Undergraduates.
Summary: An excellent primer for any organic synthesis course.
Rating: 5
Warrens book "Organic Synthesis: The Disconnection Approach" serves as an excellent bridge between the elementary education received at the undergraduate level and the more complex problems faced by synthetic practitioners. Strictly speaking, the book does not stray much beyond the complement of reactions that are learned at the undergraduate level, so much of the chemistry should be familiar to anyone having taken a two semester course. The strength of this rather short book lies in its ability to identify synthetic challenges by analyzing the retrosynthetic disconnections that create them.
Chapters alternate between the identification of a retrosynthetic disconnection and a discussion of a synthetic strategy. The book is valuable in that it distinguishes seemingly related compounds, such as 1,3-dicarbonyl compounds and 1,4-dicarbonyl compounds, and exposes the need for different synthetic strategies in each case - normal synthon polarity in the first case and inverse, or "umpolung", polarity in the second. Identifying relationships between functional groups in a molecule is presented as a means to determining possible strategies for its synthesis. Other important topics that are addressed include synthetic planning (order of events), stereochemistry, ring formation, reconnection, heterocycles, radical species, and many others.
Overall, students should expect to gain competency in the retrosynthetic analysis of molecules of moderate complexity. The book overlooks many modern day methods, but prepares students well for a graduate level synthesis course that would include such methods and gives students a better appreciation for the problems these new methods address. In my opinion, it is one of the best introductions available. In combination with the recently published sequel "Organic Synthesis: Strategy and Control", which addresses many modern day strategies, an excellent foundation has been laid for the education of up-and-coming synthetic chemists.
Summary: Published 1991
Rating: 5
This book to me is better then the synthon approach book by Warren. This has more explanation than just, you do this to get this, and so forth. Again this book is most def for the graduate student, but don't be afraid to pick this up along with the workbook. Remember this not a "textbook" it is a book with a specific agenda, exactly what the title says.
Summary: good, but a bit dated
Rating: 3
This is the first and only edition of this book, which, while it explains all the theory behind retrosynthesis quite well, is a bit lacking in some of the techniques that have (I presume) been discovered since it was published some 25 years ago. It's mostly there, but just make sure you consult some different sources for specific things, like 1,4 relationships (there's no mention of 1,3-dithianes at all in this book). All in all though, a thorough and reasonably accessible treatment of the topic.

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